What is determined in the IR Combi analysis?

1. HS-CRP
2. Antibodies to oxidized LDL cholesterol
3. Glucose (fasting)
4. Insulin
5. C-peptide
6. Homocysteine

What is determined in the IR Combi PLUS analysis?

1. HS-CRP
2. Antibodies to oxidized LDL cholesterol
3. Glucose (fasting)
4. Insulin
5. C-peptide
6. Homocysteine
7. Uric acid
8. Gamma GT
9. AST
10. ALT

Why?

1. Insulin resistance is often accompanied by systemic inflammatory activity known as “low-grade inflammation.” High-sensitivity CRP is a good parameter for determining this.
2. Antibodies against oxidized LDL cholesterol are an important indicator of cardiovascular disease (a common manifestation of insulin resistance).
3. Fasting glucose concentration, together with insulin, allows for the determination of the HOMA insulin resistance index, a scientifically documented measure for determining the degree of insulin resistance.
4. C-Peptide: When evaluating endogenous insulin reserves, determining C-peptide in peripheral blood offers several advantages over insulin. Unlike insulin, C-peptide is largely removed from the blood upon first passage through the liver. Therefore, this value in peripheral blood provides a more reliable indication of beta cell activity than the insulin level itself. Furthermore, when using exogenous insulin, there is a high risk of developing antibodies that complicate insulin determination. Moreover, it is impossible to distinguish exogenous insulin from endogenous insulin. C-peptide assays allow this, and are not affected by antibody formation.
5. Homocysteine: a major risk factor for cardiovascular disease.
6. Uric acid. Acidification of the body, muscles, and joints is usually caused by a daily excess of acid-forming foods. After being metabolized, acid-forming foods leave behind acidic waste products such as uric acid, lactic acid, and acetic acid. Because the body cannot eliminate all of this excess acid, the excess acid is stored in the body. Elevated uric acid in the blood can result in gout.
7. Gamma GT. Gamma GT (GGT or gamma-glutamyltransferase) is a liver enzyme. It is a substance in the liver that breaks down food, drink, and waste products.
8. AST/ALT. The AST (aspartate aminotransferase)/ALT (alanine aminotransferase) test measures the degree of liver damage. AST and ALAT are liver enzymes. An elevated AST/ALT level can indicate liver damage. Liver damage can be caused by alcohol consumption, but also by hepatitis, medication, or other liver diseases.

After placing your order, you will receive:

1. an email with a lab form for this analysis in the order confirmation. Download this form and fill in your details.
2. Within a few days, you will receive a package from the lab containing several blood tubes. The package includes a letter with information about the location of a PMO blood collection center near you. Call the lab’s phone number (see the letter) and schedule an appointment near you.

On the day of your appointment, bring the lab form and the package of tubes to the blood collection clinic.

After the blood collection, place the tubes and the completed lab form in the provided sealable bag and send the envelope to the address on the sealable bag.

Please note:

1. You must be fasting for the analysis. This means: Do not consume coffee or dairy products (such as milk, buttermilk, or yogurt) after 11:00 PM the evening before your appointment. No fried foods or alcoholic beverages. For breakfast and/or lunch, eat a maximum of two slices of whole-wheat bread topped with, for example, lean meat products, without butter. Drink water or tea without milk or sugar. Do not consume sweet spreads, fruit, or dairy products.
2. You must mail the envelope containing the tubes the day before your blood collection time. Do not mail on Fridays, as the blood will take too long to arrive. On warm or very cold days, deposit the tubes as close to your blood collection time as possible, or preferably, drop them off at a PostNL Service Point. Do not include them in parcels, but with regular mail. Due to the packaging, it will then be treated as medical mail.
   Store the blood at room temperature until shipping.
3. Blood collection is not permitted for children under the age of 17. This group is classified as “incapacitated” and therefore cannot have their blood drawn independently.